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Fusion Protein | 融合蛋白质

 

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融合蛋白

融合蛋白有两种不同的含义, 一种是通过DNA重组技术得到的两个基因重组后的表达产物。另一种含义就是介导两个细胞质膜融合的一组蛋白。(中文解释尚需完善,请参照下面的英文解释)

 

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Fusion proteins, also known as chimeric proteins, are proteins created through the joining of two or more genes which originally coded for separate proteins. Translation of this fusion gene results in a single polypeptide with function properties derived from each of the original proteins.

The functionality of fusion proteins is made possible by the fact that many protein functional domains are modular. In other words, the linear portion of a polypeptide which corresponds to a given domain, such as a tyrosine kinase domain, may be removed from the rest of the protein without destroying its intrinsic enzymatic capability.

Naturally occurring fusion genes are most commonly created when a chromosomal translocation replaces the terminal exons of one gene with intact exons from a second gene. This creates a single gene which can be transcribed, spliced, and translated to produce a functional fusion protein. Many important cancer-promoting oncogenes are fusion genes produced in this way.

Several drugs made from chimeric proteins are currently available for medical use. Several chimeric protein drugs are TNFα blockers, such as Etanercept, Infliximab, and Adalimumab.

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